Catalog No.
CS029026
Species reactivity
Human
Applications
Research Grade Biosimilar
Host species
Humanized
Isotype
IgG4-kappa
Expression system
Mammalian Cells
Clonality
Monoclonal
Target
T-cell immunoglobulin mucin receptor 3, HAVcr-2, TIMD-3, T-cell membrane protein 3, HAVCR2, Hepatitis A virus cellular receptor 2, CD366, TIMD3, TIM-3, TIM3, T-cell immunoglobulin and mucin domain-containing protein 3
Concentration 1.56mg/mlEndotoxin level
Please contact the lab for this information.
Purity
>95% purity as determined by SDS-PAGE.
Purification
Protein A/G, purified from cell culture supernatant.
Accession
Q8TDQ0
Form
Liquid
Storage buffer
0.01M PBS,pH7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -277°C.
Alternate Names
MBG-453,CAS:2252262-24-9
Background
Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells.
Note
For research use only. Not for use in clinical or therapeutic applications.
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