Catalog No.

CS029036

Species reactivity 

Human

Applications 

Research Grade Biosimilar

Host species 

Humanized

Isotype 

IgG1-Kappa

Expression system 

Mammalian Cells

Clonality

Monoclonal

Target 

T-cell immunoglobulin mucin receptor 3, HAVcr-2, TIMD-3, T-cell membrane protein 3, HAVCR2, Hepatitis A virus cellular receptor 2, CD366, TIMD3, TIM-3, TIM3, T-cell immunoglobulin and mucin domain-containing protein 3

Concentration 

1mg/ml

Endotoxin level

Please contact the lab for this information.

Purity 

>95% purity as determined by SDS-PAGE.

Purification 

Protein A/G, purified from cell culture supernatant.

Accession 

Q8TDQ0

Form 

Liquid

Storage buffer

0.01M PBS,pH7.4.

Stability and Storage 

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -709°C.

Alternate Names 

BGB-A425,CAS:2342597-90-2

Background 

Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer.

Note

For research use only. Not for use in clinical or therapeutic applications.