Catalog No.
CS941016
Species reactivity
Human
Applications
Research Grade Biosimilar
Host species
Humanized
Isotype
IgG2-Kappa
Expression system
Mammalian Cells
Clonality
Monoclonal
Target
TNF- and APOL-related leukocyte expressed ligand 2, APRIL, CD256, Tumor necrosis factor ligand superfamily member 13, TNF-related death ligand 1, TALL-2, TNFSF13, ZTNF2, A proliferation-inducing ligand, TALL2, TRDL-1
Concentration
1.5mg/ml
Endotoxin level
Please contact the lab for this information.
Purity
>95% purity as determined by SDS-PAGE.
Purification
Protein A/G, purified from cell culture supernatant.
Accession
O75888
Form
Liquid
Storage buffer
0.01M PBS,pH7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -707°C.
Alternate Names
VIS-649,CAS:2382896-07-1
Background
Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody which inhibits a proliferation-inducing ligand (APRIL). Sibeprenlimab suppresses pathogenic immunoglobulins (IgA and IgM), while preserving antibody responses to mRNA-based vaccines against SARS-COV-2. Sibeprenlimab reduces urinary protein-to-creatinine ratio (UPCR) and glomerular filtration rate (GFR). Sibeprenlimab is promising for the research of IgA nephropathy (IgAN).
Note
For research use only. Not for use in clinical or therapeutic applications.
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