生物活性:Concanavalin A is a Ca2+/Mn2+-dependent and mannose/glucose-binding plant lectin that can be found in jack bean. Concanavalin A can induce programmed cell death. Concanavalin A can be used to induce acute hepatic injury[1] .
体内研究(In Vivo): Concanavalin A (20 mg/kg; i.v.) 诱导小鼠自身免疫性 肝炎。
Animal Model: 6-8 weeks, 20 g Male Balb/c mice[3]
Dosage: 20 mg/kg
参考文献
[1]. Li W, et, al. Concanavalin A: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics. Biochem Biophys Res Commun. 2011 Oct 22;414(2):282-6.