MLN4924 (MLN4924) 是一种有效的选择性 NEDD8 激活酶 (NAE) 抑制剂,IC50 为 4.7 nM。
Cas No.
905579-51-3
SDF
别名
氨基磺酸[(1S,2S,4R)-4-[4-[[(1S)-2,3-二氢-1H-茚-1-基]氨基]-7H-吡咯并[2,3-D]嘧啶-7-基]-2-羟基环戊基]甲基酯,MLN4924
化学名
[(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate
Canonical SMILES
C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=O)N
分子式
C21H25N5O4S
分子量
443.53
溶解度
≥ 22.2mg/mL in DMSO
储存条件
Store at -20°C
General tips
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Note:仅用于科学研究,不为任何个人或者非科研性质的用途提供产品和服务。