产品描述

Anticancer antibiotic，antiviral and antiprotozoal activity.

生物活性

Distamycin is an antibiotic that binds the minor groove of duplex DNA at AT‐rich regions and induces a specific activation of transcriptional initiation by binding to non-alternating AT sequences in the spacer DNA.

名称

偏端霉素 A

纯度

≥90%

分子量

481.51

分子式

C22H27N9O4

CAS No.

39389-47-4

存储

Store in a tight container at -20°C.

参考文献

[1] Cocco M J, Hanakahi L A, Huber M D, et al. Specific interactions of distamycin with G‐quadruplex DNA[J]. Nucleic acids research, 2003, 31(11): 2944-2951.

[2] Khalaf A I, Waigh R D, Drummond A J, et al. Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity[J]. Journal of medicinal chemistry, 2004, 47(8): 2133-2156.

[3] Dorn A, Affolter M, Müller M, et al. Distamycin‐induced inhibition of homeodomain‐DNA complexes[J]. The EMBO journal, 1992, 11(1): 279-286.

Note

For research use only.