产品描述

A jadomycin is an anacyclic natural product produced by Streptomyces venezuelae ISP5230.

别名

杰多霉素

纯度

≥95%

分子量

549.57

分子式

C30H31NO9

CAS No.

149633-99-8

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

参考文献

1. Hall SR, Toulany J, Bennett LG, Martinez-Farina CF, Robertson AW, Jakeman DL, Goralski KB. Jadomycins Inhibit Type II Topoisomerases and Promote DNA Damage and Apoptosis in Multidrug-Resistant Triple-Negative Breast Cancer Cells. J Pharmacol Exp Ther. 2017 Nov;363(2):196-210. doi: 10.1124/jpet.117.241125. Epub 2017 Sep 13. PubMed PMID: 28904004.

2. Li L, Pan G, Zhu X, Fan K, Gao W, Ai G, Ren J, Shi M, Olano C, Salas JA, Yang K. Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase. Appl Microbiol Biotechnol. 2017 Jul;101(13):5291-5300. doi: 10.1007/s00253-017-8256-y. Epub 2017 Apr 20. PubMed PMID: 28429060.

3. Zhu J, Sun D, Liu W, Chen Z, Li J, Wen Y. AvaR2, a pseudo γ-butyrolactone receptor homologue from Streptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth. Mol Microbiol. 2016 Nov;102(4):562-578. doi: 10.1111/mmi.13479. Epub 2016 Aug 25. PubMed PMID: 27502190.

4. Wang W, Yang T, Li Y, Li S, Yin S, Styles K, Corre C, Yang K. Development of a Synthetic Oxytetracycline-Inducible Expression System for Streptomycetes Using de Novo Characterized Genetic Parts. ACS Synth Biol. 2016 Jul 15;5(7):765-73. doi: 10.1021/acssynbio.6b00087. Epub 2016 May 6. PubMed PMID: 27100123.

Note

For research use only.