产品名称：吲哚菁绿ICG炔烃

CAS：1622335-40-3

规格：1mg

储存条件：-15℃避光防潮

保质期：24个月

产品物理化学光谱特性

分子量：768.03

外观：固体

溶剂：DMSO

激发波长(nm)：780

发射波长(nm)：800

产品介绍

吲哚菁绿（ICG）是一种三碳菁型染料，具有NIR吸收特性（峰值吸收约780 nm），最大发射波长约为800 nm。这种染料也称为Cardio Green和其他一些较不常见的商品名。 FDA批准了非侵入性近红外（NIR）荧光成像染料ICG进行眼科血管造影，以确定心输出量以及肝血流量和功能。由于红外频率穿透视网膜层，因此与荧光素血管造影相比，ICG血管造影可以成像更深的循环模式。 ICG与血浆蛋白紧密结合，并局限于血管系统。 ICG的半衰期为150到180秒，只能从肝脏转移至胆汁而从循环系统中移除。最近的一项研究表明，ICG可在注射后20分钟内靶向动脉粥样硬化，并为体内检测动脉粥样硬化兔中富含脂质，发炎，冠状动脉粥样斑块提供了足够的信号增强。离体荧光反射成像显示，与注射盐水的带有粥样斑块的兔子相比，注射了ICG的带有粥样斑块的兔子的斑块靶标与背景比率高。它还可用于其他医学诊断和癌症患者中，用于实体瘤的检测，淋巴结的定位以及在重建手术期间的血管造影，视网膜和脉络膜血管的可视化以及光动力疗法。在癌症诊断和治疗中，ICG既可以用作显像染料又可以用作热疗剂。在可见光范围内几乎没有吸收，这是由于低自发荧光，组织吸收和在近红外波长（700-900 nm）下的散射引起的。这种ICG炔烃可用于通过众所周知的点击化学方法化学选择性标记叠氮基（叠氮化物）标记的生物分子（如蛋白质，脂质，核酸，糖）。

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