产品名称：巴豆醛-HSA（人血清白蛋白）缀合物

规格：100ug

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：N/A

溶剂：水

产品介绍

巴豆醛是一种常见的环境污染物。烟草烟雾是巴豆醛的重要来源。巴豆醛也自然存在于某些水果和蔬菜、精选乳制品和一些酒精的饮料中。除了这些外源性来源外，巴豆醛也是在脂质过氧化（LPO）过程中内生形成的，LPO可能是导致不吸烟者血清中醛类存在的一个因素。与其他不饱和醛一样，巴豆醛具有许多毒理学特性，包括在实验动物中引起多器官毒性的能力；在体外的DNA损伤和致突变性；在体内的致癌性。将巴豆醛加入牛血清白蛋白（BSA）中，制备了巴豆醛-BSA缀合物。我们的巴豆醛-牛血清白蛋白缀合物完全具有巴豆醛/蛋白质的定义比率，这是其他供应商没有提供的。它已用于制备抗巴豆醛抗体和发展巴豆醛定量分析。

参考文献

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Authors: Zhang, Biao and Wei, Ping and Men, Jinlong and Zhang, Shuman and Shao, Hua and Zhang, Zhihu
Journal: Toxicology mechanisms and methods (2020): 19-32

Resolution and Quantitation of Mercapturic Acids Derived from Crotonaldehyde, Methacrolein, and Methyl Vinyl Ketone in the Urine of Smokers and Nonsmokers.
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A computational foray into the mechanism and catalysis of the adduct formation reaction of guanine with crotonaldehyde.
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Journal: Molecules (Basel, Switzerland) (2019)

Autophagy induced by low concentrations of crotonaldehyde promotes apoptosis and inhibits necrosis in human bronchial epithelial cells.
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Journal: Ecotoxicology and environmental safety (2019): 169-177

Effect of influent pH on hydrolytic acidification performance and bacterial community structure in EGSB for pretreating crotonaldehyde manufacture wastewater after ozonation.
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Long-term exposure to crotonaldehyde causes heart and kidney dysfunction through induction of inflammatory and oxidative damage in male Wistar rats.
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