产品展厅
产品展厅
| 中文名 | 水飞蓟宾 |
|---|---|
| 英文名 | Silibinin |
| 中文别名 | 水飞蓟宾(混有A和B) | 2,3-二氢-3-(4-羟基-3-甲氧基苯基)-2-羟甲基-6-(3,5,7-三羟基-4-氧代苯并吡喃-2-基)苯并二氧六环 | 水飞蓟素,西利马林.益肝灵 | 水飞蓟素 | 西利马林 |
| 英文别名 | 更多 |
| 描述 | Silibinin为抗癌和化疗预防化合物，能抑制细胞增殖和迁移。 |
|---|---|
| 相关类别 |
信号通路 >> 自噬 >> 自噬
研究领域 >> 癌症
天然产物 >> 黄酮类化合物
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| 参考文献 |
[1]. Woo SM, et al. Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation. Chem Biol Interact. 2014 Jan 16;211C:36-43. [2]. Kim TH, et al. Silibinin induces cell death through ROS-dependent down-regulation of Notch-1/ERK/Akt signaling in human breast cancer cells. J Pharmacol Exp Ther. 2014 Jan 28. [3]. Zhang S, et al. Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells. PLoS One. 2013 Dec 27;8(12):e83699. [4]. Khan AQ, et al. Silibinin Inhibits Tumor Promotional Triggers and Tumorigenesis Against Chemically Induced Two-Stage Skin Carcinogenesis in Swiss Albino Mice: Possible Role of Oxidative Stress and Inflammation. Nutr Cancer. 2013 Dec 23. [5]. Khazim K, et al. The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo. Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F691-700. |
