Thiol-PEG-COOH (MW 5000) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5000(Average)

C??H??NO?S

SCCC(NCCOCCOCCCC(O)=O)=O.[MW 5000].[n]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21.