Pactimibe sulfate
2021-03-10
产品详情
- Cas：608510-47-0
- 价格：3000
- 产品名称Pactimibe sulfate
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- 简介
Pactimibe sulfate (CS-505) is a dual?ACAT1/2?inhibitor with?IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibits?ACATwith?IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively[1]. Pactimibe sulfate (CS-505) noncompetitively inhibits?oleoyl-CoA?with a?Ki?value of 5.6 μM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits?cholesteryl ester formation?with an?IC50?of 6.7 μM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity
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