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Description
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Triclopyr, a foliar systemic herbicide and fungicide, is widely used for broadleaf and woody plant control. Triclopyr has severe toxicity[1] .
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In Vitro
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Triclopyr (3 mM; 48 hours) treatment exhibits cytotoxicity against N2a cells[1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cytotoxicity Assay[1]
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Cell Line:
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Mouse neuroblastoma (N2a) cells
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Concentration:
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3 mM
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Incubation Time:
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48 hours
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Result:
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Decreased significantly for cell viability (P < 0.0001) compared to the untreated N2a cells.
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In Vivo
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Pharmacokinetic Analysis
Triclopyr exhibits moderate half-lives (dog 25 h and monkey 6.3 h) due to plasma clearance (18 mL/h/kg, 26 mL/h/kg respectively) following oral gavage (3 male beagle dogs ;0.5 mg/kg, 5 mg/kg and 20 mg/kg) and intravenous administration (1 male rhesus monkey; 30 mg/kg) [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:
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3 male beagle dogs(7.2 - 7.9 kg), 1 male rhesus monkey [2]
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Dosage:
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0.5 mg/kg, 5 mg/kg, 20 mg/kg (beagle dog); 30 mg/kg (rhesus monkey)
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Administration:
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Oral gavage (beagle dog); intravenous (rhesus monkey)
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Result:
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T1/2s of 25 and 6.3 h for dogs and a monkey, respectively.
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Molecular Weight
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Formula
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CAS No.
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中文名称
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SMILES
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OC(COC1=NC(Cl)=C(Cl)C=C1Cl)=O
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Shipping
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Room temperature in continental US; may vary elsewhere.
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Storage
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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[1]. Tejaswini P Reddy, et al. Toxicity of neurons treated with herbicides and neuroprotection by mitochondria-targeted antioxidant SS31. Int J Environ Res Public Health. 2011 Jan;8(1):203-21.
[2]. C Timchalk, et al. Pharmacokinetics of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) in the beagle dog and rhesus monkey: perspective on the reduced capacity of dogs to excrete this organic acid relative to the rat, monkey, and human. Toxicol Appl Pharmacol. 1997 Jun;144(2):268-78.
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