653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC₅₀ of 26.3 μM^[1] .

653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

407.29

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1224567-46-7

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.