IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H₂O₂-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death^{[1] [2]} .

IM-54 selectively inhibits oxidative stress-induced necrosis, but it does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis^[1] .
IM-54 shows strong inhibition of H₂O₂-induced necrosis, with an IC₅₀ of 0.25 μM against HL-60 cells treated with H₂O₂^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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• [1]. Kosuke Dodo, et al. Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury. ACS Med Chem Lett. 2018 Mar 8; 9(3): 182–187.

  [2]. Mikiko Sodeoka, et al. Development of selective inhibitors of necrosis. Chem Rec. 2010 Oct;10(5):308-14.