SKF 100398 (d(CH2)5Tyr(Et)VAVP) is an arginine vasopressin (AVP) analogue, and acts as a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP^[1] .

SKF 100398 is a specific antagonist of the hydrosmotic effect of exogenous and endogenous AVP^[1] .
SKF 100398 (8 μg/kg; i.v.) abolishes the antidiuretic effect of AVP^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1136.39

C??H??N??O??S?

77453-01-1

{(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: 1-Cys6)

{(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-YFVNCPRG-NH2 (Disulfide bridge: 1-Cys6)

Room temperature in continental US; may vary elsewhere.

• [1]. S Ishikawa, et al. Further in vivo evidence for antagonist-to-antidiuretic action of arginine vasopressin. Am J Physiol. 1983 Nov;245(5 Pt 1):R713-9.