Iodoacetyl-LC-biotin is a biotinylated electrophile probe that can be used to investigate the scope and characteristics of protein covalent binding to subcellular proteomes^{[1] [2]} .

Iodoacetyl-LC-biotin (IAB) (50-200 μM; 6-24 h) increases LDH leakage in HEK293 cells in a time- and dose-dependant manner^[1] .
IAB (50-200 μM; 24 h) causes the release of cytochrome c from the mitochondria to the cytosol in HEK293 cells^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

510.43

C??H??IN?O?S

93285-75-7

O=C(NCCCCCCNC(CI)=O)CCCC[C@H]1[C@](NC2=O)([H])[C@](N2)([H])CS1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wong HL, et, al. Mitochondrial protein targets of thiol-reactive electrophiles. Chem Res Toxicol. 2008 Apr;21(4):796-804.

  [2]. Davis KA, et, al. Staining of cell surface human CD4 with 2'-F-pyrimidine-containing RNA aptamers for flow cytometry. Nucleic Acids Res. 1998 Sep 1;26(17):3915-24.