Cortisol sulfate
2021-03-08
产品详情
- 产地 中国
- Cas:1253-43-6
- 价格:100
- 产品名称Cortisol sulfate
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- 简介
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Description
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Cortisol sulfate (Cortisol 21-sulfate) is a metabolite of Cortisol (HY-N0583). Cortisol sulfate is a specific ligand for intracellular transcortin[1] [2] [3] .
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In Vivo
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Cortisol sulfate (3 mg; i.m.; every other day; for 2-7 weeks) affects behavior through its direct action on the central nervous system[4] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:
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Male Wistar-King rats[4]
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Dosage:
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3 mg
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Administration:
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Intramuscular injection, every other day, for 2-7 weeks
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Result:
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Had significant stimulatory effects on the animal's exploratory behaviors (ambulation and rearing), when the treatments were started soon after weaning (postnatal day 21-24).
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Molecular Weight
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Formula
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CAS No.
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中文名称
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SMILES
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C[C@]([C@@]1(O)C(CO[S](=O)(O)=O)=O)(C2)[C@](CC1)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])[C@H]2O
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Shipping
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Room temperature in continental US; may vary elsewhere.
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Storage
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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[1]. C S Hall, et al. Simultaneous metabolism of cortisol sulfate and cortisol in normal human adults. J Clin Endocrinol Metab. 1970 Oct;31(4):439-44.
[2]. S S Singer, et al. Enzymatic sulfation of steroids: I. The enzymatic basis for the sex difference in cortisol sulfation by rat liver preparations. Endocrinology. 1976 Apr;98(4):963-74.
[3]. T Hayashi, et al. Cortisol-21-sulfate (FS) is a specific ligand for intracellular transcortin: demonstration of three types of high affinity corticosteroid binders in bovine aortic cytosol by a combined use of FS and RU 28362. Endocrinology. 1990 Jan;126(1):307-16.
[4]. S Miyabo, et al. Behavioral and other systemic effects of cortisol-21 sulfate. Horm Behav. 1972 Sep;3(3):227-36.
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