Neurotensin Receptor^[1]

[D-Trp11]-Neurotensin (0.13-1.1 μM) markedly inhibits NT-induced coronary vessel constriction in perfused rat hearts^[1] .
[D-Trp11]-Neurotensin (2-110 μM) exhibits NT-like activity in perfused rat hearts^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

[D-Trp11]-Neurotensin (50-500 nmol/kg; i.v.) has hypotensive activity in pentobarbital-anesthetized rats, with an ED₂₅ of 122 nmol/kg^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1695.96

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73634-68-1

{Pyr}-LYENKPRRP-{D-Trp}-IL

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

In Vitro: 

H₂O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

 ContentsAssign valueAcidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

3.  Recommended solution:

Overall charge of peptideDetailsNegative (<0)1.  Try to dissolve the peptide in water first.2.  If water fails, add NH4OH (<50 μL).3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.Positive (>0)1.  Try to dissolve the peptide in water first.2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.Zero (=0)1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

• [1]. Quirion R, et, al. Selective blockade of neurotensin-induced coronary vessel constriction in perfused rat hearts by a neurotensin analogue. Eur J Pharmacol. 1980 Feb 8;61(3):309-12.

  [2]. Quirion R, et, al. Hypotensive effects of centrally and peripherally administered neurotensin and neurotensin derivatives in rats. Neuropeptides. 1981 Jou. 1(4): 253-9.