货号（Catalog No.）

CSD00199

通用名INN

Daratumumab

纯度(Purity)

>95%

浓度( Concentration)

1mg/ml

Formulation

PBS buffer pH7.5

Source

CHO cells

内毒素(Endotoxin level)

Please contact with the lab for this information.

生物活性

产品描述(Description)

Daratumumab is a human monoclonal antibody that targets CD38, a cell surface protein that is overexpressed on multiple myeloma (MM) cells.

别名(Alternative names)

HuMax-CD38

靶点;物种(Specificity target name;species)

CD38[Homo sapiens]

活性研究（体外/体内研究）(Activity in vitro)

Daratumumab was studied in a series of in vitro assays and was found to induce CDC in freshly isolated MM cells obtained from the bone marrow of 13 previously untreated or relapsed MM patients. Furthermore, daratumumab triggered antibody-dependent cell-mediated cytotoxicity (ADCC) in CD38-expressing MM cell lines in peripheral blood mononuclear cells (PBMCs) enriched for NK cells, as well as in patient MM cells in the presence of both autologous and allogeneic effector cells.

种类(Species)

Homo sapiens

受体鉴定(Receptor identification)

IgG1-kappa

化学信息

分子量(MV)

148000.00 Da

CAS

945721-28-8

存储条件(Storage)

store at -80°C

Note
For research use only. Not suitable for clinical or therapeutic use.