货号（Catalog No.）

CSD00157

通用名INN

Denosumab

纯度(Purity)

>95%

浓度( Concentration)

1mg/ml

Formulation

PBS buffer pH7.5

Source

CHO cells

内毒素(Endotoxin level)

Please contact with the lab for this information.

生物活性

产品描述(Description)

Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption markers in patients with a variety of metastatic tumors and is being investigated in multiple clinical trials for the prevention and treatment of bone metastases. Chemically, it consists of 2 heavy and 2 light chains. Each light chain consists of 215 amino acids. Each heavy chain consists of 448 amino acids with 4 intramolecular disulfides. FDA approved on June 1, 2010.

别名(Alternative names)

AMG162

靶点;物种(Specificity target name;species)

TNFSF11/CD254[Homo sapiens]

种类(Species)

Homo sapiens

受体鉴定(Receptor identification)

IgG2-kappa

化学信息

分子量(MV)

144700.00 Da

CAS

615258-40-7

存储条件(Storage)

store at -80°C

Note
For research use only. Not suitable for clinical or therapeutic use.