Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody,prevents binding of IL-6 to the IL-6R,thereby inhibiting both classic and trans-signaling.Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis.

货号（Catalog No.）icon

ATAD00661

通用名INNicon

Tocilizumab

纯度(Purity)icon

>95%

电泳图（SDS-PAGE image）icon

浓度( Concentration)icon

1mg/ml

Formulationicon

PBS buffer pH7.5

Sourceicon

CHO cells

内毒素(Endotoxin level)icon

Please contact with the lab for this information.

产品描述(Description)icon

Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody,prevents binding of IL-6 to the IL-6R,thereby inhibiting both classic and trans-signaling.Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis.

别名(Alternative names)icon

Atlizumab,MRA/R-1569/RHPM-1/RO-4877533

靶点;物种(Specificity target name;species)icon

IL-6R

活性研究（体外/体内研究）(Activity in vitro)icon

Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1-100 ng/mL; 24 hours, 48 hours) inhibits the cell proliferation (growth rate) in a dose-dependent manner, growth rate by HACM is reduced almost completely by 100 ng/mL tocilizumab.
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (0.001-10,000 μg/ml; 2 days) inhibits Ba/F3-gp130-IL-6R cell proliferation stimulated with hIL-6 with an IC50 of 13.5 ng/ml.
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1 μM; 6 hours) reduces the phosphorylation of STAT3 in vitro consistent with in vivo SAS cells.
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1-5 μM; 24 hours) significantly reduces VEGF mRNA expression in SAS cells with serum-free medium.

受体鉴定(Receptor identification)icon

IgG1

CASicon

375823-41-9

存储条件(Storage)icon

store at -80°C