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| 常用名 | ALB-127158(a)中 | 英文名 | ALB-127158(a) |
|---|---|---|---|
| CAS号 | 1173154-32-9 | 分子量 | N/A |
| 密度 | N/A | 沸点 | N/A |
| 分子式 | N/A | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
ALB-127158(a) 是一种有效的选择性黑色素浓缩激素 1 (MCH1) 受体拮抗剂。
Fields of Application :
ALB-127158A, also known as ALB-127158(a), is a MCH1 antagonist for the treatment of obesity.
| CAS Number: | 1173154-32-9 |
| Purity: | >98% |
| Molecular Weight: | 404.44 |
| Molecular Formula: | C23H21FN4O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | ALB-127158A; ALB 127158A; ALB127158A; ALB-127158(a); ALB127158(a); ALB 127158(a); ALB-127158; ALB 127158; ALB127158,1173154-32-9 |
| Chemical Name: | 2(1H)-Pyridinone, 4-[(5-fluoro-2-pyridinyl)methoxy]-1-(2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-7-yl)- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
reclinical studies demonstrated that the compound produced significant weight loss in rodents. ALB-127158(a) may be a potential treatment for IBD. This example demonstrates how using data from the preclinical studies is possible to build decision points into an early clinical development plan that will allow early assessment of potential efficacy and allow timely go/no go decisions.The study, comprising the single ascending dose (SAD) and 14-day multiple ascending dose (MAD) arms, included standard safety assessments, ECG monitoring, and PK measurements. ALB-127158(a) was well tolerated in both the SAD and the MAD. Reported events were mild and showed little dose relationship.
References:
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