产品展厅
产品展厅
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | JNJ-10229570 | 英文名 | JNJ-10229570 |
|---|---|---|---|
| CAS号 | 524923-88-4 | 分子量 | 389.47000 |
| 密度 | N/A | 沸点 | N/A |
| 分子式 | C22H19N3O2S | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
JNJ-10229570 是肾上腺皮质受体 1 (MC1R) 和肾上腺皮质受体 5 (MC5R) 的拮抗剂，可抑制皮脂腺分化和皮质特异性脂质的产生，其抑制 125I-NDP-α-MSH 和人类细胞中 MC1R 和 MC5R 结合的 IC50 值分别为 270 nM 和 200 nM。
Fields of Application :
JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively.
| CAS Number: | 524923-88-4 |
| Purity: | >98% |
| Molecular Weight: | 389.47 |
| Molecular Formula: | C22H19N3O2S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | JNJ-10229570; JNJ10229570; JNJ 10229570 |
| Chemical Name: | Benzenamine, N-(2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene)- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
References:
COC1=CC=CC=C1C2=N/C(SN2C3=CC=CC=C3OC)=N\C4=CC=CC=C
