CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent.
| 常用名 | 曲他齐卡 | 英文名 | Tretazicar |
|---|---|---|---|
| CAS号 | 21919-05-1 | 分子量 | 252.184 |
| 密度 | 1.7±0.1 g/cm3 | 沸点 | 427.2±45.0 °C at 760 mmHg |
| 分子式 | C9H8N4O5 | 熔点 | N/A |
| MSDS | 美版 | 闪点 | 212.2±28.7 °C |