AZD 5153 is an orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4 (IC50?= 5 nM).?It can simultaneously bind two bromodomains in BRD4, which has been shown to increase antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma.

AZD5153 6-羟基-2-萘甲酸用途：

AZD5153 6-Hydroxy-2-naphthoic acid是AZD5153的6-羟基-2-萘甲酸盐形式。AZD5153是一种有效选择性，有口服活性的BET/BRD4溴结构域抑制剂; 干扰BRD4的IC50值为1.7nM。